Academic Centre
Postdoctoral project :Nr. 1.1.1.2/VIAA/3/19/525 “Intestinal inflammation as a potentially modifiable risk factor for complications in type 1 diabetes”
Partner: Latvian Biomedical Research and Study centre, Riga, Latvia. Folkhalsan Research center, Helsinki, Finland
This project aims to evaluate association between faecal markers of intestinal inflammation, serum markers of endotoxaemia and dietary factors in patients with type 1 diabetes and different rate of progression of diabetic nephropathy
The dataset contains information on 74 patients with type 1 diabetes (T1D) and 39 generally healthy subjects (control group), recruited during the ERDF postdoctoral project Nr. 1.1.1.2/VIAA/3/19/525 “Intestinal inflammation as a potentially modifiable risk factor for complications in type 1 diabetes”. The aim of the project is to reveal associations between signs and symptoms of diabetic gastroenteropathy, serum and faecal inflammatory markers and dietary habits.
Recruitment took place between 15th of January 2021 and 31st of August 2021 in Latvia, Riga. Subjects in the control group were with normal glucose metabolism.
Exclusion criteria for both study groups were: pregnancy, history of inflammatory bowel disease (Crohn disease or Ulcerative colitis) and coeliac disease, acute intestinal infection within 2 months of the planned faecal collection, asymptomatic coeliac disease (detected via screening of serum transglutaminase IgA antibodies), clinical signs of acute inflammation, fever.
The dataset includes data of diabetes history (duration, complications such as diabetic kidney disease, cardiovascular disease, neuropathy, retinopathy), medication usage (including ACI/ARB and other hypotensive agents, lipid lowering medications, drugs for control of gastroenteropathy symptoms and other), comorbidities, laboratory test results (glucose, HbA1c, lipids, liver enzymes, serum creatinine, blood count etc). Further, 17 questions on frequency and severity of symptoms of diabetic gastroenteropathy (gastrointestinal symptom score) are included. We also report the levels of inflammation and endotoxaemia in serum: hsCRP, lipopolysaccharide-binding protein (LBP), endoCab IgG and IgM, endotoxin, and faecal calprotectin. Data on diet include food frequency questionnaire, 24-hour dietary recall and 3 day food diary. Food frequency questionnaire covers 118 food products from 20 food groups, snacks and drinks. In 24-hour dietary recall and 3-day food diary, for accurate portion size assessment, validated portion size picture book and food weighting was used.
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