Project title:Multimodal Optical Imaging for Personalized Hemodynamic Phenotyping of Microcirculation in Septic Patients
Project number: lzp-2024/1-0501
Project implementer: University of Latvia (UL)
Project manager: Uldis Rubīns
The lead institution in the implementation of the project in UL isFaculty of Science and Technology
Project implementation period: 01.01.2025. – 31.12.2027.
Project funding: 300 000 EUR
About the project:
Sepsis, a life-threatening systemic response to infection, affects an estimated 49.8 million patients worldwide annually and carries a mortality rate of 19.2%. It can rapidly escalate from localized infection to severe organ dysfunction and septic shock. Abnormalities in microcirculatory perfusion, leading to suboptimal tissue oxygenation, are critical to sepsis progression. Despite advancements in sepsis management, the high mortality rate underscores the need for novel personalized strategies. An interdisciplinary team of biophotonics experts and clinicians seeks to address this gap by developing an optical imaging technique for personalized hemodynamic phenotyping of microcirculation in septic patients. The proposed technique integrates active dynamic thermography and narrow-band imaging, offering non-invasive, real-time evaluation of microcirculatory perfusion for patient phenotyping. The project aims to develop a prototype device suitable for bedside use in intensive care units. Using the imaging data, unique physiological phenotypes will be identified, paving the way for personalized patient management strategies. This approach is anticipated to significantly improve clinical outcomes, reduce associated costs and morbidity, and revolutionize sepsis management.
Scientific group:
Project scientific leader:
Dr. Phys. Uldis Rubīns, ULFaculty of Science and Technology.
Leading participants:
- Dr. Phys. Andris Grabovskis;
- Prof. Dr. Biol. Zbigņevs Marcinkevičs;
- Dr. Med. Sigita Kazūne.
Participants: Matīss Briuks(medicalresident) un Megija Nordena (bachelor student).
Project Achievements
| Indicators of impact of results | Completed for the half-life of the project (30.06.2026) | Planned for the end of the project (31.12.2027) |
Original scientific articles published, submitted or accepted for publication in Q1 or Q2 quartile issues included in the Web of Science or SCOPUS databases | 0 | 2 |
Original scientific articles published in other publications included in the Web of Science or SCOPUS databases | 1 | 3 |
Clinical trial dataset developed within the project and prepared in accordance with FAIR principles | 1 | 1 |
A new technology combining active dynamic thermography and narrowband spectral image visualization for real-time microcirculation assessment for phenotyping sepsis patients | 1 | 1 |
Project application submitted to the Latvian Research and Development Project Competition | 1 | 1 |
Publications (SCOPUS)
Z. Marcinkevics, M. Nordena, U. Rubins, A. Grabovskis.Multimodal imaging for cutaneous microcirculation assessment using active thermography and remote photoplethysmography. SPIE Proc. Vol. 14094, paper 14094-95, DOI 10.1117/12.3100263
Participation in the conference with a poster presentation
SPIE Photonics Europe– 2016 (12-16.04.2026),Z. Marcinkevics: ”Multimodal imaging for cutaneous microcirculation assessment using active thermography and remote photoplethysmography”.
Scientists' Night 2025 event
Venue: University of Latvia Science House (27.09.2025), topic: “Application of active thermography and narrowband spectroscopy in blood circulation monitoring”