Conclusions are that pyridine is found to be the most promising biomarker candidate for detecting gastric cancer. The difference in the volatilomic signatures can be explained by cancer-related changes in the activity of certain enzymes, or pathways. The results of this study confirm that the chemical fingerprint formed by volatiles in gastric tissue is altered by gastric cancer.
The paper was prepared by Pawel Mochalski, along with Daria Ślefarska-Wolak representing Jan Kochanowski University of Kielce Institute of Chemistry, and University of Innsbruck Insitute of Breath Research, Mārcis Leja, representing Digestive Diseases Centre GASTRO and, along with Linda Mežmale, Institute of Clinical and Preventive Medicine, Faculty of Medicine, University of Latvia and Riga East University Hospital. The publication was also prepared by Veronika Patsko of National Cancer Institute of Ukraine, Clemens Ager and Chris A. Mayhew, representing University of Innsbruck Insitute of Breath Research, Agnieszka Królicka from AGH University of Science and Technology Faculty of Materials Science and Ceramics Department of Building Materials Technology, and Gidi Shani and Hossam Haick from Technicon—Israel Institute of Technology Russel Berrie Nanotechnology Institute Department of Chemical Engineering.
The article is openly accessible on ‘Diagnostics’: https://www.mdpi.com/2075-4418/13/3/335
