Antimikrobiālās bioenerģētikas laboratorija

• Baktēriju un antimikrobiālo savienojumu mijiedarbības bioenerģētika.
• Antimikrobiālie peptīdi (AMP), to darbības mehānismi un saistība starp baktēriju AMP rezistenci un to enerģētisko metabolismu.
• Rekombinanto AMP ražošanas metaboliskā inženierija.
• Rekombinanto producentu kultivēšanas optimizācija bioreaktoros un mērogošanas (scale-up) protokolu izstrāde.

Laboratorijas vadītājs, Vadošais pētnieks

Reinis Rutkis

G. Behrendt, R. Rutkis, U. Kalnenieks and K. Bettenbrock, Investigating the role of FOF1 ATPase in Zymomonas mobilis Through Deletion of Its FO and F1 Subunits. (2025) ID is: 9131862.Microbial Biotechnology (In Revision).

M. Rubina, I. Strazdina, R. Rutkis, U. Kalnenieks (2025), The promoter of Zymomonas mobilis respiratory NADH dehydrogenase (ndh) is induced by oxygen, Journal of Biotechnology, 402, doi.org/10.1016/j.jbiotec.2025.03.005.

R. Rutkis, Z. Lasa, M. Rubina, I. Strazdina, and U. Kalnenieks (2024) Eminent Antimicrobial Peptide Resistance in Zymomonas mobilis: A Novel Advantage of Intrinsically Uncoupled Energetics. Antibiotics,13,451. doi.org 10.3390/antibiotics13050451

I. Strazdina, M. Bikerniece, E.R. Paegle, K. Shvirksts, M. Grube, Z. Lasa, R. Rutkis, and U. Kalnenieks (2023) Oxidative Phosphorylation for Aerobic Survival, but Not for Growth: The Peculiar ‘Make-Accumulate-Consume’ Strategy in Zymomonas mobilis. Fermentation 9: 951. doi.org/10.3390/ fermentation9110951

K. Kovtuna, I. Strazdina, M. Bikerniece, N. Galinina, R. Rutkis, J. Martynova and U. Kalnenieks (2022) Improved hydrogen peroxide stress resistance of / NADH dehydrogenase (ndh) and alcohol dehydrogenase (adhB) mutants. Fermentation 8:289.

R. Rutkis, Z. Ļaša, M. Rubina. R. Ščerbaka, G. Kalniņš, J. Bogans and U. Kalnenieks (2022) Antimicrobial activity of Zymomonas mobilis is related to its aerobic catabolism and acid resistance. Fermentation 8:77.

I. Strazdina, L. Klavins, N. Galinina, K. Shvirksts, M. Grube, E. Stalidzans and U. Kalnenieks (2021) Syntrophy of Crypthecodinium cohnii and immobilized Zymomonas mobilis for docosahexaenoic acid production from sucrose-containing substrates. Journal of Biotechnology 338:63-70.

U. Kalnenieks, K.M. Pappas, K. Bettenbrock (2020) Zymomonas mobilis metabolism: novel tools and targets for its rational engineering. Advances in Microbial Physiology 77:37-88.

U. Kalnenieks, E. Balodite, and R. Rutkis (2019) Metabolic Engineering of Bacterial Respiration: High vs. Low P/O and the Case of Zymomonas mobilis. Frontiers in Bioengineering and Biotechnology 7:327.

U. Kalnenieks, E. Balodite, S. Strähler, I. Strazdina, J. Rex, A. Pentjuss, K. Fuchino, P. Bruheim, R. Rutkis, K.M. Pappas, R.K. Poole, O. Sawodny and K. Bettenbrock (2019). Improvement of acetaldehyde production in Zymomonas mobilis by engineering of its aerobic metabolism. Frontiers in Microbiology 10:2533.

“Ilgtspējīgas un multimodālas bakteriālas platformas izstrāde ādas un mīksto audu infekciju ārstēšanai” ERAF projekts (2025–2028);

“Jauni no Zymomonas mobilis iegūti antimikrobiālie peptīdi pielietojumam ādas un mīksto audu infekciju terapijā” ERAF projekts (2020–2023);

“Process optimisation for improved c-19 vaccine production.” (2020-2021) Saiba AG, Switzerland,

“A novel bacterial system with integrated micro-bubble distillation for the production of acetaldehyde.” ERA IB 6th call.

Laboratorijas vadītājs

Dr.biol. Reinis Rutkis

E-pasts reinis.rutkis@lulv 

Telefona nr: +371 29129436 

Fakss: +371 67034885