Cell Biology

“Study of mechanisms of anhydrobiosis and resistance to dehydration-rehydration treatments in yeasts”, Latvian-French Bilateral Research Cooperation Project (2020-2021).

“Exploring the organellar homeostasis in senescent yeast model: mechanisms and implications for geriatric health”, Latvian-Lithuanian-Taiwanese Trilateral Research Cooperation Project (2025-2027).

“Investigation of intracellular changes during anhydrobiosis in yeast applicable for biomedicine and biotechnology”, Latvian-Lithuanian-Taiwanese Trilateral Research Cooperation Project (2016-2018).

“Development of new approaches for waste-less simultaneous production of bioethanol, furfural and other valuable products from local agricultural waste material”, Project of European Fund for Regional Development (2017-2020).

“Engineered surface platform for immobilization of microorganisms”, Latvian Council of Science (2018-2021).

“Waste-less technology for the production of bioethanol and other valuable products from wood”, Project of European Fund for Regional Development (2011-2013).

“The development of new preparations of biopesticides with increased activities and stability for the improvement of efficiency of biological (organic) agriculture”, Latvian-Belarus Bilateral Research Cooperation Grant (2012-2013).

“Anhydrobiosis in yeasts and its non-conventional biotechnological applications”, Latvian Council of Science (2013-2016).

“Biotechnological basis for joint production of bioethanol and furfural from wheat straw”, Project of European Fund for Regional Development (2014-2015).

“Studies of yeast anhydrobiosis mechanisms”, Latvian-French Bilateral Research Cooperation Project (2014-2015).

“Investigations of Molecular Mechanisms of Yeast Resistance to Dehydration and of Applied Aspects of Anhydrobiosis of Microorganisms”, Latvian Council of Science (2005-2008). 

“Extreme combined radiation influence upon the eukaryotic cell model”, Ministry of Education and Science of Latvia (2007).

“Supersonic hydrodynamical shock influence on the eukaryotic cell model and blood cells”, Ministry of Education and Science of Latvia (2008).

“Working out and application in the production of biopesticides of new methods of physiological activation of bacteria-producers with the goal to increase the efficiency and stability of their actiivity”, Bilateral project between Belarus and Latvia (2007-2011).

“Investigations of General Mechanisms of Microorganisms Response Upon Stress Treatments at Ultrastructural and Molecular Levels”, Latvian Council of Science (2001-2004).

“Multifunctional Percolated Nanostructured Ceramics Fabricated from Hydroxylapatite”, EU 6th Framework Programme (2004-2007).

“Xylitol protection of eukariotic cells in extreme conditions and dehydration influence upon pentose metabolism in yeast cells”, CIMO (Finland) (2005).

Grant from Danish Research Council for the joint investigations of yeasts cells biosorption activity (1994‑96).“Molecular Mechanisms of Dehydration-Rehydration and Osmotic Stress in Yeasts”, Latvian Council of Science (1997-2000).

“General Mechanisms of Yeast Cell Reactions to Heavy Metals”, Latvian Council of Science (1997-2000).

“Dehydration of Recombinant Microorganisms”, CNRS (France) (1997-98).

"General Mechanisms of Intracellular Reactions to Extreme Treatments", Latvian Council of Science (1994‑96).

"Influence of Chromium (VI) on Yeasts", Latvian Council of Science (1994‑96).

"General Mechanisms of the Reversible Delay (Anhydrobiosis) of Yeast Metabolism", International Science Foundation (J.Soros's Foundation, USA) (1994‑95).

3 Grants from Swedish Institute for the joint investigations of intracellular protective reactions in yeasts cells (1993‑95).

M.Saubenova (Kazakhstan), A.Rapoport, Z.Yermekbay (Kazakhstan), Y.Oleinikova (Kazakhstan). Antimicrobial peptides, their production, and potential in the fight against antibiotic-resistant pathogens. Fermentation, 2025, 11, 36. doi.org/10.3390/fermentation11010036

S.Dahiya (India), A.Rapoport, B.Singh (India). Biotechnological potential of lignocellulosic biomass as substrates for fungal xylanases and its bioconversion into useful products: A review. Fermentation 2024, 10, 82. doi.org/10.3390/fermentation10020082

Anu (India), Alokika (India), R.C.Kuhad (India), A.Rapoport, V.Kumar (India), D.Singh (India), V.Kumar (India), S.Kumar Tiwari (India), S.Ahlawat (India), B.Singh (India). Biolohical pretreatment of lignocellulosic biomass: An environmental-benign and sustainable approach for conversion of solid waste into value-added products. Critical Reviews in Environmental Science and Technology 2024, 54:10, 771-796,  https://doi.org/10.1080/10643389.2023.2277670

K.Timmis (Germany) et al. A concept for international societally relevant microbiology education and microbiology knowledge promulgation in society. Microbial Biotechnology, 2024, 17 (5), e14456 doi.org/10.1111/1751-7915.14456

M.Saubenova (Kazakhstan), Y.Oleinikova (Kazakhstan), A.Rapoport, S.Maksimovich (Kazakhstan), Z.Yermekbay (Kazakhstan), E.Khamedova (Kazakhstan). Bioactive peptides derived from whey proteins for health and functional beverages. Fermentation, 2024, 10, 359. doi.org 10.3390/fermentation10070359

M.Saubenova (Kazakhstan), A.Rapoport, M.Venkatachalam (France), L.Dufossé (France), Z.Yermekbay (Kazakhstan), Y.Oleinikova (Kazakhstan). Production of carotenoids by microorganisms. Fermentation, 2024, 10, 502. doi.org/10.3390/fermentation10100502

N.Vedernikovs, G.Khroustalyova, I.Muiznieks, A.Rapoport. New concept for conversion of lignocellulose to ethanol and furfural. Applied Microbiology and Biotechnology, 2023, 107, 535-542 doi.org/10.1007/s00253-022-12353-8

Y.Dekhtyar, D.Abols, L.Avotina, A.Stoppel (Germany), S.Balakin (Germany), G.Khroustalyova, J.Opitz (Germany), H.Sorokins, N.Beshchasna (Germany), P.Tamane, A.Rapoport. Effects of diamond nanoparticles immobilisation on the surface of yeast cells: a phenomenological study. Fermentation, 2023, 9, 162 doi.org/10.3390/fermentation902016

M.Saini (India), Anu (India), A.Rapoport, S.K.Tiwari (India), D.Singh (India), V.Malik (India), S.Kumar (India), B.Singh (India). Bioacetoin production by Bacillus subtilis subsp. subtilis using enzymatic hydrolysate of lignocellulosic biomass. Fermentation, 2023, 9, 698. doi.org/10.3390/fermentation9080698

W.Sek (Poland), A.M.Kot (Poland), A.Rapoport. M.Kieliszek (Poland). Physiological and genetic regulation of anhydrobiosis in yeast cells. Archives of Microbiology 2023, 205, 348. doi.org/10.1007/s00203-023-03683-w

M.G.Saubenova (Kazakhstan), A.Rapoport, E.A.Oleinikova (Kazakhstan), S.V.Maksimovich (Kazakhstan), Zh.N.Ermekbay (Kazakhstan). Efficiency of feeder yeast and their derivatives in animal husbandry. Microbiology and Virology (Almaty) 2023, 4 (43), 63-70

A.Rapoports, G.Hrustaļova, H.Sorokins, J.Dehtjars, L.Saulīte, L.Rozenfelde. Uz funkcionalizēta nesēja virsmas imobilizētu rauga šūnu fermentatīvi sintezētā etanola noteikšanas metode (Method for determination of ethanol enzymatically synthesized by yeast cells immobilized on a surface of functionalized carrier). Latvijas patents 2023, LV 15753 B1

E.Bondareva, Y.Dekhtyar, V.Gorosko, H.Sorokins, A.Rapoport. Correlation of statistical distributions of the dimension of yeast cells attached to the substrate and its surface electrical potential. Materials, 2022, 15, 6 doi.org/10.3390/ma15010006

L Žorža, M Kalniņš, D Gudrā, K Megnis, D Fridmanis, A Rapoport, O Muter. Changes in bacterial community structure in wastewaters in the presence of Saccharomyces cerevisiae and benzalkonium chloride. IOP Conf. Ser.: Earth Environ. Sci. 2022, 987, 012010

Y.N.Nagaraj (Sweden), V.Burkina (Czech Republic), L.Okmane (Sweden), J.Blomqvist (Sweden), A.Rapoport, M.Sandgren (Sweden), J.Pickova (Sweden), S.Sampels (Sweden), V.Passoth (Sweden). Identification, quantification and kinetic study of carotenoids and lipids in Rhodotorula toruloides CBS 14 cultivated on wheat straw hydrolysate. Fermentation, 2022, 8, 300 doi.org/10.3390/fermentation8070300

L.Rozenfelde, M.Puke, N.Vedernikovs, R.Scherbaka, A.Rapoport. Catalytic treatment of rapeseed straw for enhanced production of furfural and glucose for bioethanol production. Process Biochemistry, 2021, 102, 102-107 doi.org/10.1016/j.procbio.2020.12.007

A.Rapoport, I.Guzhova (Russia), L.Bernetti (Italy), P.Buzzini (Italy), M.Kieliszek (Poland), A.M.Kot (Poland). Carotenoids and some other pigments from fungi and yeasts. Metabolites, 2021, 11 (2), 92 doi.org/10.3390/metabo11020092

N.Kuliešiene (Lithuania), R.Žukiene (Lithuania), G.Khroustalyova, C.-R.Chang (Taiwan), A.Rapoport, R.Daugelavičius (Lithuania). Changes in energy status of Saccharomyces cerevisiae cells during dehydration and rehydration. Microorganisms 2021, 9, 444. doi.org/10.3390/microorganisms9020444

E.Dauss, K.Papouškova (Czech Republic). H.Sychrova (Czech Republic). A.Rapoport. Anhydrobiosis in yeast: role of cortical endoplasmic reticulum protein Ist2 in Saccharomyces cerevisiae cells during dehydration and subsequent rehydration. Antonie van Leeuwenhoek, 2021, 114 (7), 1069-1077 doi.org/10.1007/s10482-021-01578-8

C.‐L.Chen (Taiwan), Y.‐C.Chen (Taiwan), W.‐L.Huang (Taiwan), S.Lin (Taiwan), R.Daugelavičius (Lithuania), A.Rapoport, C.-R.Chang (Taiwan). A crucial role of mitochondrial dynamics in dehydration resistance in Saccharomyces cerevisiae. Int. J. Mol. Sci. 2021, 22, 4607. doi.org/10.3390/ijms22094607

J.E.Hallsworth (UK), R.L.Mancinelli (USA), C.A.Conley (USA), T.D.Dallas (UK), T.Rinaldi (Italy), A.F.Davila (USA), K.C.Benison (USA), A.Rapoport, B.Cavalazzi (Italy), L.Selbmann (Italy), H.Changela (China, USA), F.Westall (France), M.M.Yakimov (Italy), R.Amils (Spain), M.T.Madigan (USA). Astrobiology of life on Earth. Environmental Microbiology, 2021, 23(7), 3335–3344 https://doi:10.1111/1462-2920.15499

G.Makarenkova, V.Balode, D.Zala, E.Azena, A.Rapoport, I.Muiznieks. Effect of pretreated colza straw on the growth and extracellular ligninolytic enzymes production by Lentinula edodes and Ganoderma lucidum. Fermentation, 2021, 7 (3), 157 doi.org/10.3390/fermentation7030157

R.Vasylyshyn (Ukraine), O.Kurylenko (Ukraine), J.Ruchala (Poland), N.Shevchuk (Ukraine), N.Kuliesiene (Lithuania), G.Khroustalyova, A. Rapoport, R.Daugelavicius (Lithuania), K.Dmytruk (Ukraine), A.Sibirny (Ukraine, Poland). Engineering of sugar transporters for improvement of xylose utilization during high-temperature alcoholic fermentation in Ogataea polymorpha yeast. Microbial Cell Factories, 2020, 19:96 doi.org/10.1186/s12934-020-01354-9

Anu (India), A.Kumar (India), A.Rapoport, G.Kunze (Germany), S.Kumar (India), D.Singh (India), B.Singh (India). Multifarious pretreatment strategies for the lignocellulosic substrates for the generation of renewable and sustainable biofuels: A review. Renewable Energy, 2020, 160, 1228-1252 doi.org/10.1016/j.renene.2020.07.031

V.P.Cojocaru (Moldova),  H.-N.L.Teodorescu (Romania), J.Dehtjars, A.Rapoport, A.Starsaja. Experimental setup with chaotic and periodic excitations for cell growth studies. International Conference on Applied Electronics, 2020, 9232828

P.G.Hamill (UK), A.Stevenson (UK), P.E.McMullan (UK), J.P.Williams (UK), A.D.R.Lewis (UK), S.Sudharsan (India), K.E.Stevenson (UK), K.D.Farnsworth (UK), G.Khroustalyova, J.Y.Takemoto (USA), J.P.Quinn (UK), A.Rapoport, J.E.Hallsworth (UK). Microbial lag phase can be indicative of, or independent from, cellular stress. Scientific Reports, 2020, 10:5948 doi.org/10.1038/s41598-020-62552-4

D.Kulikova-Borovikova, S.Lisi (Italy), E.Dauss, T.Alamae (Estonia), P.Buzzini (Italy), J.E.Hallsworth (UK), A.Rapoport. Activity of the a-glucoside transporter Agt1 in Saccharomyces cerevisiae cells during dehydration-rehydration events.- Fungal Biology, 2018, 122 (6), 613-620 doi.org/10.1016/j.funbio.2018.03.006

J.Brandenburg (Sweden), I.Poppele, J.Blomqvist (Sweden), M.Puke, J.Pickova (Sweden), M.Sandgren (Sweden), A.Rapoport, N.Vedernikovs, V.Passoth (Sweden). Bioethanol and lipid production from the enzymatic hydrolysate of wheat straw after furfural extraction.- Appl. Microbiol. Biotechnol., 2018, 102, 6269-6277 DOI: 10.1007/s00253-018-9081-7

D.Kulikova-Borovikova, G.Khroustalyova, Chuang-Rung Chang (Taiwan), R.Daugelavicius (Lithuania), M. Yurkiv (Ukraine), J.Ruchala (Poland), A.Sibirny (Ukraine), A.Rapoport. Anhydrobiosis in yeast: glutathione overproduction improves resistance to dehydration of a recombinant Ogataea (Hansenula) polymorpha strain.- Process Biochemistry, 2018, 71, 41-44 DOI: 10.1016/j.procbio.2018.05.016

A.Rapoport. Anhydrobiosis and dehydration of yeasts (Review).- In: Biotechnology of Yeasts and Filamentous Fungi (Ed. A.Sibirny). Springer International Publishing, 2017, 87-116 (DOI: 10.1007/978-3-319-58829-2_4)

N.Matjuskova, L.Okmane, D.Zala, L.Rozenfelde, M.Puke, I.Kruma, N.Vedernikovs, A.Rapoport. Effect of lignin-containing media on growth of medicinal mushroom Lentinula edodes. Proceedings of the Latvian Academy of Sciences. Section B, 2017, 71(1-2), 38-42 (DOI: 10.1515/prolas-2017-0007)

L.Rozenfelde, M.Puke, I.Kruma, I.Poppele, N.Matjuskova, N.Vedernikovs, A.Rapoport. Enzymatic hydrolysis of lignocellulose for bioethanol production.- Proceedings of the Latvian Academy of Sciences. Section B, 2017, 71(4), 275-279 (DOI: 10.1515/prolas-2017-0046)

D.Borovikova, R.Teparic (Croatia), V.Mrsa (Croatia), A.Rapoport. Anhydrobiosis in yeast: cell wall mannoproteins are important for yeast Saccharomyces cerevisiae resistance to dehydration. Yeast, 2016, 33, 8, 347-353 DOI: 10.1002/yea.3164

A.Rapoport, B.Turchetti (Italy), P.Buzzini (Italy). Application of anhydrobiosis and dehydration of yeasts for non-conventional biotechnological goals (Review).- World J. Microbiol. Biotechnol., 2016, 32(6):104 (DOI: 10.1007/s11274-016-2058-8)

M.Duskova (Czech Republic), D.Borovikova, P.Herynkova (Czech Republic), A.Rapoport, H.Sychrova (Czech Republic). The role of glycerol transporters in yeast cells in various physiological and stress conditions. FEMS Microbiol. Lett., 2015, 362, 3, 1-8 (DOI: http://dx.doi.org/10.1093/femsle/fnu041)

J.Liepins, E.Kovačova (Slovak Republic), K.Shvirksts, M.Grube, A.Rapoport, G.Kogan (Slovak Republic). Drying enhances immunoactivity of spent brewer’s yeast cell wall beta-D-glucans J. Biotechnology, 2015, 206, 12-16 (DOI: dx.doi.org/10.1016/j.jbiotec.2015.03.024)

A.Rapoport, H.Heipieper (Germany). Biotechnological and environmental microbiological research in the Baltic region. Biotechnology and Applied Biochemistry, 2014, 61, 1-2 (doi: 10.1002/bab.1210).

D.Borovikova, R.Scherbaka, A.Patmalnieks, A.Rapoport. Effects of yeast immobilisation on bioethanol production. Biotechnology and Applied Biochemistry, 2014, 61, 33-39  (doi: 10.1002/bab.1158).

D.Borovikova, P.Herynkova (Czech Republic), A.Rapoport, H.Sychrova (Czech Republic). Potassium uptake system Trk2 is crucial for yeast cell viability during anhydrobiosis. FEMS Microbiol. Lett., 2014, 350, 28-33 (doi: 10.1111/1574-6968.12344).

A.Rapoport, N.Vedernikov, I.Kruma, M.Puke, D.Borovikova, L.Rozenfelde, G.Khroustalyova, N.Matyuskova. Waste-less bioethanol and other valuable substances production from hardwood.- WIT Transactions on Engineering Sciences, 2014, vol. 88, pp. 311-317.

L.Rozenfelde, A.Rapoport. Anhydrobiosis in yeast: is it possible to reach anhydrobiosis for yeast grown in conditions with severe oxygen limitation?- Antonie van Leeuwenhoek Journal of Microbiology, 2014, 106, 2, 211-217 (doi: 10.1007/s10482-014-0182-8)

D.Borovikova, L.Rozenfelde, I.Pavlovska, A.Rapoport. Immobilisation increases yeast cells resistance to dehydration-rehydration treatment.- J. Biotechnology, 2014, vol. 184, pp. 169-171 (doi: 10.1016/j.jbiotec.2014.05.017)

M.Grube, M.Gavare, L.Rozenfelde, A.Rapoport. Anhydrobiosis in yeast: FT-IR spectroscopic studies of yeast grown under conditions of severe oxygen limitation. Biotechnology and Applied Biochemistry, 2014, 61, No. 4, pp. 474-479 (doi: 10.1002/bab.1165)

A.Rapoport, A.Rusakova, G.Khroustalyova, G.Walker (UK). Thermotolerance  in Saccharomyces cerevisiae is  linked to resistance to anhydrobiosis. Process Biochemistry, 2014, vol. 49, 1889-1892 (doi:10.1016/j.procbio.2014.07.006)

S.Dupont (France), A.Rapoport, P.Gervais (France), L.Beney (France). The survival kit of Saccharomyces cerevisiae for anhydrobiosis (Review).- Applied Microbiology and Biotechnology, 2014, 98, 21, 8821-8834 (doi 10.1007/s00253-014-6028-5)

A.Rapoport, G.Khroustalyova, L.Rozenfelde, D.Borovikova, E.Kolomiets (Belarus). Anhydrobiosis in microorganisms and new biotechnological solutions. – In: Microbial Biotechnologies: Fundamental and Applied Issues. Minsk, Belaruskaya navuka, 2013, vol. 5, pp.141-154 (in Russian).

O.Muter, A.Rapoport. Some physiological aspects of chromium sorption by yeasts. Lambert Academic Publishing, 2013, 114 p.

A.Rapoports, N.Vedernikovs, L.Rozenfelde, J.Dehtjars, S.Cifanskis, M.Puke, I.Kruma, A.Katasevs, V.Jakusevics. Method of enzymatic pre-treatment of cellulose.- Latvian Patent, 2013, LV14742 B

L.Rozenfelde, G.Khroustalyova, M.Mandryk (Belarus), E.Kolomiets (Belarus), A.Rapoport. Physiological engineering of Pseudomonas aurantiaca antimicrobial activity: effects of NaCl treatments. Microbiology Research, 2012, vol. 3, No. 2, e26, pp. 108-111

A.Rapoport, D.Borovikova, A.Kokina, A.Patmalnieks, N.Polyak, I.Pavlovska, G.Mezinskis, Yu.Dekhtyar. Immobilisation of yeast cells on the surface of hydroxyapatite ceramics. Process Biochemistry, 2011, 46, 665-670  (doi: 10.1016/j.procbio.2010.11.009)

Yu.Trofimova, G.Walker (UK), A.Rapoport. Anhydrobiosis in yeast: influence of calcium and magnesium ions on yeast resistance to dehydration-rehydration. FEMS Microbiology Letters, 2010, 308, 55-61 (doi: 10.1111/j.1574-6968.2010.01989.x)

E.I.Кolomiets (Belarus), A.I.Rapoport, A.V.Sviridov (Belarus), O.S.Кilchevskaya (Belarus), V.N.Кuptsov (Belarus), T.V.Romanovskaya (Belarus). Clamp rot pathogens activity of sugar beet and new methods of their control. Advances in Agricultural Sciences (Warsaw), 2010, 554, 93-100.