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Laboratory of Cell Biology
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Head - Cor. Memb. of Latvian Academy of Science,
Prof., Dr. Hab. Biol. Alexander Rapoport
http://www.lza.lv/scientists/rapoport.htm
rapoport@latnet.lv
Phone: +371 703 4891; fax: +371 722 7925

PROJECTS

  "General Mechanisms of Intracellular Reactions to Extreme Treatments", Latvian Council of Science (1994-1996).

"Influence of Chromium (VI) on Yeasts", Latvian Council of Science (1994-1996).

"General Mechanisms of the Reversible Delay (Anhydrobiosis) of Yeast Metabolism", International Science Foundation (J.Soros's Foundation, USA) (1994-1995).

3 Grants from Swedish Institute for the joint investigations of intracellular protective reactions in yeasts cells (1993-1995).

Grant from Danish Research Council for the joint investigations of yeasts cells biosorption activity (1994-1996).

"Molecular Mechanisms of Dehydration-Rehydration and Osmotic Stress in Yeasts", Latvian Council of Science (1997-2000).

"General Mechanisms of Yeast Cell Reactions to Heavy Metals", Latvian Council of Science (1997-2000).

"Dehydration of Recombinant Microorganisms", CNRS (France) (1997-1998).

"Investigations of general mechanisms of microorganisms response upon stress treatments at ultrastructural and molecular levels", Latvian Council of Science (2001-2004).

COOPERATION PARTNERS

  • University of Goteborg, Sweden (Prof. Lennart Adler)
  • University of Lund, Sweden (Prof. Barbel hahn-Hagerdal)
  • University of California, Davis, USA (Prof. John H.Crowe)
  • University of Paris XI, France (Prof. Bernar Arrio, Dr. Maria Zinovieva)
  • National Polytechnical Institute of Lorraine, France (Prof. Joseph Boudrant)
  • Institute of Cytology, Russian Academy of Science, Russia (Dr. Irina Guzhova)
  • Universita degli studi della Basilicata, Italy (Prof. Patrizia Romano)

6 EU FRAMEWORK PROGRAMME

If you could be interested in the areas of investigations in which we have the experience and if you plan to participate in 6th EU Framework Programme we kindly invite you to communicate with us by fax (+371 722 7925) or e-mail (rapoport@latnet.lv). We will be glad to discuss with you the possibilities of our joint project application.



 





MAIN DIRECTIONS OF INVESTIGATIONS

MAIN RESULTS

  • The main scientific interests of laboratory are linked with the studies of anhydrobiosis of microorganisms. Summarizing the results received it could be said that these investigations gave a possibility just not only to study this extremely interesting natural phenomenon of reversible delay of metabolism but to reveal the main mechanisms of intracellular reactions under unfavourable conditions of environment too. It was shown that extreme dehydration influences all intracellular structures. We revealed the main structural and functional changes of yeast cell wall, plasma membrane, mitochondria, vacuoles, lysosomal apparatus and nuclei. Made experiments have shown that the main factors determining the cell resistance to dehydration are the following: the level of intracellular nucleic acid stability, the cell cycle stage, the possibility of maintenance by cells the molecular organization of intracellular membranes and ability of "switching on" by cells of the whole complex of protective reactions at early stages of dehydration process. A whole number has been demonstrated of earlier unknown self-protective reactions observed in eucaryotic organisms under extreme environmental conditions (ability of the cells to limit irreversibly damaged cytoplasm sites, to separate with the help of nucleolemma chromatine-containing nucleus parts, chromatine condensing, etc.). We showed the possibility of directed increase of cell resistance to dehydration by the way of special osmotic treatment on yeast. It was established the stabilization of intracellular membrane state was achieved in these conditions.
    We found new very interesting model object for the further investigations of anhydrobiosis - osmotolerant yeast Debaryomyces hansenii which is extremely resistant to dehydration-rehydration. It was shown the possibility of this yeast to synthesize additional quantities of glycerol during dehydration procedure. We revealed that the membranes of this yeast differs from S. cerevisiae - they have very low phase transition temperature for lipids. We received also data that the ability to produce xylitol by different xylose-utilizing yeasts - Pichia stipitis, Pachysolen tannophilus and transformants of S. cerevisiae correlates with their resistance to dehydration. We proposed the hypothesis that in the case of the absence of trehalose synthesis in the cells xylitol can substitute trehalose in its protection of membrane molecular organization. In the case trehalose can be synthesized xylitol can act as the additional protective substance which can protect and stabilize proteins and/or nucleic acids.
    At the same time in the realised experiments it was discovered that some of intracellular changes can significantly influence the further physiological activity of the culture and in many cases could be of interest for the modern yeast biotechnology. New interesting possibilities for the operation of cell factory functioning can be revealed at all 3 stages of dehydration-rehydration (dehydration, rehydration and reactivation). It was revealed that yeast dehydration in specific conditions can lead to the significant increase of synthesis of some normal for cell metabolism compounds which can be extracted from the biomass later. Besides that synthesis of the metabolites which are characteristic only for the stress conditions can be artificially initiated too. Another very interesting possibility is linked with unusual and  still unclear "activation phenomenon" of yeast culture in the processes of dehydration-rehydration. As the result of this phenomenon oversynthesis of some metabolites can be induced in the case of the use of dry "activated" culture as an inoculum in the subsequent fermentations. Investigations of molecular organization of intracellular membranes and of their changes showed the ways for different manipulations with their state, for example increasing or diminishing their permeability in the interests of the biotechnological processes. Structural and functional changes of cell wall also can be used in the biotechnology. One of their possible applications can be linked with the use of yeasts influenced by special treatments for the purification of the environment from heavy metals. All these examples show new interesting possibilities of the operation of cell factory activity which can be found in the further detailed investigations of different stress treatments upon yeasts.

PERMANENT STAFF

4 scientists

SCIENTIFIC SUPERVISION

1 Ph.D. thesis defended in March 2002, 1 MSc student, 1 BSc student

ACADEMIC COURSES

Faculty of Biology, University of Latvia:
M. Sc. studies
- Cytology, physiology and conservation of strain-producers, 4 credits
- Biology of yeasts, 2 credits

PUBLICATIONS

1.    A.I.Rapoport, G.M.Khroustalyova, G.J.Camanis, M.J.Beker. Yeast anhydrobiosis: permeability of the plasma membrane.- Microbiology, 1995, vol. 64, No. 2, p. 229-232 .

2.    A.Rapoport, O.Muter. Biosorption of hexavalent chromium by yeasts.- Process Biochemistry, 1995, vol. 30, No. 2, p.145-149.

3.    A.I.Rapoport, G.M.Khroustalyova, E.N.Kuklina. Anhydrobiosis in yeast: activation effect.- Brazilian Journal of Medical and Biological Research, 1997, vol. 30, No. 1, p. 9-13.

4.    I.Krallish, H.Jeppsson, A.Rapoport, B.Hahn-Hagerdal. Effect of xylitol and trehalose on dry resistance of yeasts.- Appl. Microbiol. Biotechnol, 1997, vol. 47, p. 447-451.

5.    M.Beker, A.Rapoport, U.Viesturs. Country Profile: Latvia. In: Biotechnology in the Developing World and Countries in Economic Transition (ed. G.T.Tzotzos, K.G.Skryabin). CABI Publishing, 2000, p. 106-108

6.    M.Bekers, A.Vigants, J.Laukevics, M.Toma, A.Rapoport, P.Zikmanis. The effect of osmo-induced stress on product formation by Zymomonas mobilis on sucrose.- International Journal of Food Microbiology, 2000, vol. 55, No. 1-3, p. 147-150.

7.    M.Bekers, E.Ventina, A.Karsakevich, I.Vina, A.Rapoport, D.Upite, E.Kaminska, R.Linde. Attachment of yeast to the modified stainless steel wire spheres, growth of cells and ethanol production.- Process Biochemistry, 2000, vol. 35, No. 5, p. 523-530.

8.    M.Bekers, J.Laukevics, R.Linde, A.Rapoport. Ethanol and fructose derivative production from sugar beet and grain.- In: The rising power of yeasts in science and industry. Tenth International Symposium on Yeasts. Symposium Book. Delft, The Netherlands , 2000, p. 371.

9.    M.Beker, A.Rapoport, U.Viesturs. Country Profile: Latvia. In: Biotechnology in the Developing World and Countries in Economic Transition (ed. G.T.Tzotzos, K.G.Skryabin). CABI Publishing, 2000, p. 106-108

10. M.Bekers, E.Ventina, A.Karsakevich, I.Vina, A.Rapoport, D.Upite, E.Kaminska, R.Linde. Attachment of yeast to the modified stainless steel wire spheres, growth of cells and ethanol production.- Process Biochemistry, 2000, vol. 35, No. 5, p.523-530.

11. M.Bekers, A.Vigants, J.Laukevics, M.Toma, A.Rapoport, P.Zikmanis. The effect of osmo-induced stress on product formation by Zymomonas mobilis on sucrose.- International Journal of Food Microbiology, 2000, vol. 55, No. 1-3, p. 147-150.

12.  O.Muter, E.Ventina, A.Patmalnieks, D.Millers, L.Grigorjeva, A.Rapoport. Sorption activity of yeasts and their physiological response to combined stress.- In: The rising power of yeasts in science and industry. Tenth International Symposium on Yeasts. Symposium Book. Delft, The Netherlands, 2000, p. 372-373.

13.  M.Bekers, E.Ventina, A.Karsakevich, I.Vina, A.Rapoport, D.Upite, E.Kaminska, R.Linde. Attachment of yeast to the modified stainless steel wire spheres, growth of cells and ethanol production.- Process Biochemistry, 2000, vol. 35, No. 5, p.523-530.

14.  O.Muter, A.Patmalnieks, A.Rapoport. Interrelations of the yeast Candida utilis and  Cr (VI): metal reduction and its distribution in the cell and medium.- Process Biochemistry, 2001, vol. 36, No. 10, p. 963-970.

15.  G.M.Khroustalyova, L.Adler, A.I.Rapoport. Exponential growth phase cells of the osmotolerant yeast Debaryomyces hansenii are extremely resistant to dehydration stress.- Process Biochemistry, 2001, vol. 36, No. 12, p. 1163-1166.

16.  O.Muter, D.Millers, L.Grigorjeva, E.Ventina, A.Rapoport. Cr (VI) sorption by intact and dehydrated Candida utilis cells: differences in mechanisms.- Process Biochemistry, 2001, Vol. 37, No. 5, p. 505-511.

17.  O.Muter, M.Grube, A.Rapoport. Effect of growth conditions to the Cr (VI) sorption by intact and dehydrated Candida utilis.- In  : Future trends in food and nutrition development. Elgava, 2001, p. 177-186.

18.  O.Muter, I.Lubinya, D.Millers, L.Grigorjeva, E.Ventinya, A.Rapoport. Cr (VI) sorption by intact and dehydrated Candida utilis cells in the presence of other metals.- Process Biochemistry, 2002, vol. 38, No. 1, p. 123-131.

19.  A.Rapoport, G.Khroustalyova, I.Guzhova. Anhydrobiosis of yeasts: cell adaptation to stress conditions.- In: 1st FEMS Congress of European Microbiologists. Abstract Book. Elsevier, 2003, p. 94-95.

20.  M.Bekers, M.Marauska, P.Semjonovs, M.Grube, A.Rapoport, R.Ionina. The effect of fructooligosaccharides and polyfructans on the development of bifidobacteria.- In: 1st FEMS Congress of European Microbiologists. Abstract Book. Elsevier, 2003, p. 126.

21.  A.Rapoport. Conservation of yeasts by dehydration: intracellular protective reactions. – In: ECCO XXIV. European Culture Collections: Resources for Biology and Biotechnology.  Proceedings of the Annual General Meeting of the European Culture Collections’ Organization. Riga, 2005, p. 20-21.

22.  A.Rapoport. Anhydrobiosis and dehydration stress of yeasts. In: Riga Meeting on Compehensive Cell  Biology. Abstracts. Riga, 2005, p. 41.

23.  A.I.Rapoport. Anabiosis of microorganisms: from live nature towards modern biotechnologies. – In: Proceedings of the International Conference “Ecology of Microorganisms”. Moscow, Max Press, 2006, p. 59-62.

24.  Yu. Dekhtyar, S.Popov, A.Rapoport, Yu. Trofimova. Electron radiation influence on yeast cell morphology peculiarities. – In: Materials of the International Conference “Radiation Interaction with Material and its Use in Technologies 2006”. Kaunas, 2006, p. 250.

25.  J.Liepins, P.Richard, A.Rapoport.Yeast Saccharomyces cerevisiae response to desiccation stress – proteome study. – In: 2nd FEMS Congress of European Microbiologists “Integrating Microbial Knowledge into Human Life”. Abstracts Book, Madrid, 2006, p. 256. 

26.  Yu.Dekhtyar, D.Borovikova, V.Bystrov, S.Filippov,A.Karlov, A.Katasshev, C.Meissner, G.Mezinskis, E.Paramonova, I.Pavlovska, N.Polyaka, A.Sapronova, A.Rapoport. Nanostructured hydroxyapatite ceramics as new carrier for the immobilization of yeast cells. - In: Ņanotech Northern Europe 2007. Abstracts. Helsinki, 2007, p. 88-89.

27.  A.Rapoport, D.Borovikova, A.Katashev, A.Kokina, G.Khroustalyova, A.Patmalnieks, L.Saulite, Y.Trofimova, Y.Dekhtyar. Brewers' yeast: some physiological and biotechnological characteristics. - In: From Alcoholic Beverages to Bioethanol for Transportation: a New Challenge for Fermenting Yeast. ISSY 26. Book of Abstracts. Sorrento, 2007, p. 85.

28.  J.Liepins, G.Kogan, E.Kováčová, A.Rapoport. Some aspects of desiccated brewers' and bakers' yeast beta-D-glucans and their immunological properties. In: From Alcoholic Beverages to Bioethanol for Transportation: a New Challenge for Fermenting Yeast. ISSY 26. Book of Abstracts. Sorrento, 2007, p. 41.

29.  A.Rapoport. Anhydrobiosis of yeasts: main cell reactions to dehydration may be interesting for modern biotechnologies.- In: Power of microbes in industry and environment. Central European Symposium on Industrial Microbiology and Microbial Ecology. Abstracts. Zadar, 2007, p. 25.

30.  A.Rapoport, M.Coneva. Latvian biotechnology: yesterday, today, tmorrow.- In: Belarus – Latvia: Science. Innovation. Investments. Minsk, 2007, p. 71 (in Russian).

31.  E.I.Kolomiets, A.I.Rapoport. Biological control of phytopathogens using Bacillus bacterium: current state and prospective.- In: Belarus – Latvia: Science. Innovation. Investments. Minsk, 2007, p. 77-79 (in Russian).

32.  A.Rapoports, J.Dehtjars, W.Ambroziak, D.Borovikova, A.Kokina, D.Kriegel, A.Diowksz, E.Kordialik-Bogacka, J.Berlowska, G.Koziol. Method of microorganisms immobilization on the carrier.- Latvian Patent, 2007, LV13632 B

33.  A.Rapoports, J.Dehtjars, W.Ambroziak, D.Borovikova, A.Kokina, D.Kriegel, A.Diowksz, E.Kordialik-Bogacka, J.Berlowska, G.Koziol. Method of microorganisms immobilization on the carrier.- Latvian Patent, 2007, LV13633 B

34.  I.Guzhova, I.Krallish, G.Khroustalyova, B.Margulis, A.Rapoport. Dehydration of yeast: changes in the intracellular content of Hsp 70 family proteins.- Process Biochemistry, 2008, vol. 43, N 10, p. 1138-1141. (doi:10.1016/j.procbio.2008.05.012)

35.  A.Rapoport. Anhydrobiosis of yeasts: Main intracellular reactions.- Comparative Biochemistry and Physiology, 2008, vol. A151, N 1, p. S31.

36.  D.Borovikova, S.Cifansky, Y.Dekhtyar, V.Fedotova, V.Jakushevich, A.Katashev, A.Patmalnieks, A.Rapoport. Atomic Force Microscopy Study of Yeast Cells Influenced by High Voltage Electrical Discharge.- IFMBE Proceedings, 2008, vol. 20, p. 602-605.

37.  A.Rapoports, J.Dehtjars, S.Cifanskis. Method of yeast treatment. - Latvian Patent, 2008, LV13739 B

38.  A.Rapoport. Yeast cells help us to reveal the mysteries of anabiosis.- In: 36th Annual Conference on Yeasts. Smolenice, 2008, p. 38.

39.  A.Rapoport. Anhydrobiosis – unique state of live organisms.- In: Yeasts for Human Progress. 12th International Congress on Yeasts. Book of Abstracts. Kiev, 2008, p. 310.

40.  J.Liepins, A.Rapoport. Desiccation induced oxidative stress in bakers’ yeast Saccharomyces cerevisiae.- In: Yeasts for Human Progress. 12th International Congress on Yeasts. Book of Abstracts. Kiev, 2008, p. 200.

41.  Yu.Dekhtyar, N.Polyak, D.Borovikova, A.Rapoport. Immobilization of yeast cells on the surface of hydroxyapatite ceramics.- In: Electroceramics XI. Abstracts and CD proceedings. Manchester, 2008, p. M-004-O.

42.  A.Rapoport. Anabiosis (cryptobiosis) is a natural method for the maintenance of microbial diversity.- In: III International Conference on Microbial Diversity: Current Situation, Conservation Strategy and Biotechnological Potential. Abstracts. Perm-N.Novgrod-Perm, 2008, p. 187-188.

43.  A.Rapoport. Anhydrobiosis of yeasts: current achievements and directions for further investigations.- In: Advances in Cell Biology and Biotechnology. Lviv, 2008, p. 30.

44.  I.Axenovich, M.Balode, Yu.Dekhtyar, A.Rapoport. Features of physical, microbiological, psychophysiological actions of biomechanical and energetic method.- In: Euromedica 2008. Abstracts. Hannover, 2008, p. 13-14. 

45.  С.Л.Цыфанский, Ю.Д.Дехтяр, А.И.Рапопорт, В.А.Якушевич. Использование электрогидравлической установки для воздействия на дрожжевые клетки.- Техника машиностроения, 2009, т. 70, № 2, с. 15-18.

46.  A.I.Rapoport, G.M.Khroustalyova, L.M.Crowe, J.H.Crowe. Anhydrobiosis in yeast: stabilization by exogenous lactose.- Mikrobiologiya, 2009, vol. 78, No. 5, p. 690-694.

47.  A.I.Rapoport, G.M.Khroustalyova, L.M.Crowe, J.H.Crowe. Anhydrobiosis in yeast: stabilization by exogenous lactose.- Microbiology, 2009, vol. 78, No. 5, p. 624-629.

48.  G.Khroustalyova, J.Boudrant, A.Rapoport. Resistance of a recombinant Escherichia coli to dehydration.- Cell Biology International, 2009, vol. 33, p. 1194-1195 (doi: 10.1016/j.cellbi.2009.07.001)

49.  J.Boudrant, G.Khroustalyova, A.Rapoport. Obtention d’une résistance élevée d’une souche d’Escherichia coli recombinée vis-à-vis de la déshydratation.- Récents Progrès en Génie des Procédés, 2009, 98, 149-1 – 149-6.

50.  Yu.Dekhtyar, L.Lancere, N.Polyaka, A.Rapoport, A.Rusakova, A.Sudnikovich, V.Valters. Ultraviolet radiation influences wettability and biological properties of PMMA surface.- Medical Physics in the Baltic States, 2009, 7, 69 - 7l.

51.  A.Rapoport. Dehydration of yeasts: main intracellular reactions.- In: 2nd Annual World Congress on Industrial Biotechnology 2009. Innovative Biotechnology for Sustainable Bio-economy. Seoul, 2009, p. 72.

52.  Yu.Trofimova, G.Walker, A.Rapoport. Anhydrobiosis in yeast: influence of calcium and magnesium ions on yeast resistance to dehydration-rehydration.- FEMS Microbiology Letters, 2010, vol. 308, No. 1, p. 55-61 (doi: 10.1111/j.1574-6968.2010.01989.x)

53.  E.I.Кolomiets, A.I.Rapoport, A.V.Sviridov, O.S.Кilchevskaya, V.N.Кuptsov, T.V.Romanovskaya. Clamp rot pathogens activity of sugar beet and new methods of their control.- Advances in Agricultural Sciences (Warsaw), 2010, 554, 93-100.

54.  A.Rapoport, D.Borovikova, A.Kokina, A.Patmalnieks, N.Polyak, I.Pavlovska, G.Mezinskis, Yu.Dekhtyar. Immobilisation of yeast cells on the surface of hydroxyapatite ceramics.- Process Biochemistry, 2011, vol. 46, No. 3, p. 665-670  (doi: 10.1016/j.procbio.2010.11.009)

55.  L.Rozenfelde, G.Khroustalyova, M.Mandryk, E.Kolomiets, A.Rapoport. Physiological engineering of Pseudomonas aurantiaca antimicrobial activity: effects of NaCl treatments. Microbiology Research, 2012, 3, e28, pp. 108-111  

56.  A.Rapoport. Anhydrobiosis in yeasts: main mechanisms and industrial application.- In: Bio-economy in synthetic bio-era. BIT’s 5th Annual World Congress of Industrial Biotechnology – 2012. Book of Abstracts, 2012, p. 128.

57.  A.Rapoport. Yeast cell responses to dehydration stress.- In: International Symposium on Cell Biology. Abstract Book, Livadiya, Yalta, 2012, p. 26.

58.  A.Rapoport, G.Khroustalyova, L.Rozenfelde, D.Borovikova. Anhydrobiosis in yeasts: mechanisms and applications.- In: 1st Congress of Baltic Microbiologists. Book of Abstracts. Riga, 2012, p. I 16.

59.  D.Borovikova, A.Patmalnieks, A.Rapoport. New approach for yeast immobilization,- In: 1st Congress of Baltic Microbiologists. Book of Abstracts. Riga, 2012, p. O 24.

60.  D.Borovikova, R.Scherbaka, A.Katashev, Yu,.Dekhtyar, A.Patmalnieks, A.Rapoport. Physiological characteristics of yeast immobilized on hydrogenated hydroxyapatite.= In: 1st Congress of Baltic Microbiologists. Book of Abstracts. Riga, 2012, p. P 16.

61.  M.Grube, M.Gavare, L.Rozenfelde, A.Rapoport. Anhydrobiosis in yeast: FTIR spectroscopy studies of yeast grown in anaerobic conditions. In: 1st Congress of Baltic Microbiologists. Book of Abstracts. Riga, 2012, p. P 19.

62.  L.Rozenfelde, A.Rapoport. Anhydrobiosis in yeasts: is it possible for yeast grown in anaerobic conditions? - In: 1st Congress of Baltic Microbiologists. Book of Abstracts. Riga, 2012, p. P 20.

63.  N.Vedernikov, M.Puke, I.Kruma, L.Rozenfelde, G.Khroustalyova, D.Borovikova, A.Patmalnieks, N.Matyushkova, A.Katashev, D.Borovikova, A.Patmalnieks, N.Matyushkova, A.Katashev, Yu.Dekhtyar, A.Rapoport. New approaches for waste-less bioethanol production from hardwood.- In: 1st Congress of Baltic Microbiologists. Book of Abstracts. Riga, 2012, p. P 40.

64.  A.Rapoport, G.Khroustalyova, L.Rozenfelde, D.Borovikova, E.Kolomiets. Anhydrobiosis in microorganisms and new biotechnological solutions. – In: Microbial Biotechnologies: Fundamental and Applied Issues. Minsk, Belaruskaya navuka, 2013, vol. 5, pp.141-154 (in Russian).

65.  O.Muter, A.Rapoport. Some physiological aspects of chromium sorption by yeasts. Lambert Academic Publishing, 2013, 114 p.

66.  A.Rapoports, N.Vedernikovs, L.Rozenfelde, J.Dehtjars, S.Cifanskis, M.Puke, I.Kruma, A.Katasevs, V.Jakusevics. Method of enzymatic pre-treatment of cellulose.- Latvian Patent, 2013, LV14742 B

67.  D.Borovikova, G.Kizane, P.Mekss, I.Muiznieks, A.Rapoport. Development of yeast anhydrobiosis based test system for the screening of candidate substances for cosmetics and the health care compositions. – In: FEMS 2013 5th Congress of European Microbiologists. Advancing Knowledge on Microbes. Leipzig, Germany, 2013, p. 3209.

68.  L.Rozenfelde, M.Gavare, M.Grube, A.Rapoport. Anhydrobiosis in yeast grown in anaerobic conditions. - In: FEMS 2013 5th Congress of European Microbiologists. Advancing Knowledge on Microbes. Leipzig, Germany, 2013.

69.  D. Borovikova, E. Dauss, T. Alamae, A. Rapoport. Anhydrobiosis of yeast: influence of yeast dehydration upon AGT1 permease activity. – In: Proceedings 30th ISSY Cell Surface & Organelles in Yeasts. ISSN 1336-4839, Stara Lesna, Slovakia, 2013, p.64.

70.  D. Borovikova, P. Herynkova, A. Rapoport, H. Sychrova. Potassium uptake systems are crucial for the yeast cell viability dyring anhydrobiosis. - In: Proceedings 30th ISSY Cell Surface & Organelles in Yeasts. ISSN 1336-4839, Stara Lesna, Slovakia, 2013, p.65.

71.  63. A.Rapoport, D.Borovikova, L.Rozenfelde, G.Khroustalyova. Anhydrobiosis in yeasts: current achievments and trends.- In: BioMicroWorld 2013. V International Conference on Environmental, Industrial and Applied Microbiology. Book of Abstracts. Madrid, 2013, p.527.

72.  A.Rapoport, N.Vedernikov, I.Kruma, M.Puke, D.Borovikova, L.Rozenfelde, G.Khroustalyova, N.Matyuskova. Waste-less bioethanol and other valuable substances production from hardwood.- In: FEEM 2013. 2013 International Conference on Future Energy, Environment, and Materials. Abstracts. Hong Kong, 2013, p.8.

73.  A.Rapoport. New non-conventional approaches for the solution of important tasks of modern biotechnology.- In: International Scientific Conference “Ways of Development of the Biotechnology in Turkmenistan”.  Asgabat, 2013, pp. 148—149.

74.  А.Рапопорт. Нетрадиционные подходы к решению актуальных задач современной биотехнологии.- В: Международная Научная Конференция  «Пути развития биотезнологии в Туркменистане. Тезисы докладов. Ашхабад, 2013, c. 254-255

75.  D.Zala, N.Matjuskova, I.Poppele, A.Patmalnieks, A.Rapoport (2013) Cultivation of Shiitake mycelium in the medium containing lignocellulose processing wastes.- In: IMMC 7. 7th International Medicinal Mushroom Conference. Abstracts. Beijing, p.225-226.

76.  A.Rapoport, H.Heipieper. Biotechnological and environmental microbiological research in the Baltic region – Biotechnology and Applied Biochemistry, 2014, 61, No. 1, pp.1-2  (doi: 10.1002/bab.1210).

77.  D.Borovikova, R.Scherbaka, A.Patmalnieks, A.Rapoport. Effects of yeast immobilisation on bioethanol production. – Biotechnology and Applied Biochemistry, 2014, 61, No. 1, pp.33-39  (doi: 10.1002/bab.1158).

78.  D.Borovikova, P.Herynkova, A.Rapoport, H.Sychrova. Potassium uptake system Trk2 is crucial for yeast cell viability during anhydrobiosis.- FEMS Microbiol. Lett., 2014, vol. 350, No. 1, pp.28-33 (doi: 10.1111/1574-6968.12344).

79.  A.Rapoport, N.Vedernikov, I.Kruma, M.Puke, D.Borovikova, L.Rozenfelde, G.Khroustalyova, N.Matyuskova. Waste-less bioethanol and other valuable substances production from hardwood.- WIT Transactions on Engineering Sciences, 2014, vol. 88, pp. 311-317.

80.  L.Rozenfelde, A.Rapoport. Anhydrobiosis in yeast: is it possible to reach anhydrobiosis for yeast grown in conditions with severe oxygen limitation?- Antonie van Leeuwenhoek Journal of Microbiology, 2014, 106, 2, 211-217 (doi: 10.1007/s10482-014-0182-8)

81.  D.Borovikova, L.Rozenfelde, I.Pavlovska, A.Rapoport. Immobilisation increases yeast cells resistance to dehydration-rehydration treatment.- J. Biotechnology, 2014, vol. 184, pp. 169-171 (doi: 10.1016/j.jbiotec.2014.05.017)

82.  M.Grube, M.Gavare, L.Rozenfelde, A.Rapoport. Anhydrobiosis in yeast: FT-IR spectroscopic studies of yeast grown under conditions of severe oxygen limitation.--Biotechnology and Applied Biochemistry, 2014, 61, No. 4, pp. 474-479 (doi: 10.1002/bab.1165)

83.  A.Rapoport, A.Rusakova, G.Khroustalyova, G.Walker (UK, Scotland). Thermotolerance  in Saccharomyces cerevisiae is  linked to resistance to anhydrobiosis.- Process Biochemistry, 2014, vol. 49, 1889-1892 (doi:10.1016/j.procbio.2014.07.006)

84.  S.Dupont (France), A.Rapoport, P.Gervais (France), L.Beney (France). The survival kit of Saccharomyces cerevisiae for anhydrobiosis (Review).- Applied Microbiology and Biotechnology, 2014, 98, 21, 8821-8834 (doi 10.1007/s00253-014-6028-5)

85.  A.Rapoport, I.Muiznieks, N.Vedernikov, E.Kolomiets. Modern biotechnologies: new approaches and further trends for development.- In: International Scientific Conference “Science, Technology and Innovative Technologies in the Prosperous Epoch of the Powerful State”. Abstracts. Asgabat, 2014, Vol. 1, pp. 322-323.

86.  А.Рапопорт, И.Муйжниекс, Н.Ведерников, Э.Коломиец. Современные биотехнологии: новые подходы и направления развития.- В: Международная Научная Конференция «Наука, Техника и Инновационные Технологии в Эпоху Могущества и Счастья». Матeриалы. Ашхабад, 2014, том 1, с. 320 – 322.

87.  A.Rapoport, D.Borovikova, L.Rozenfelde, O.Muter, I.Muiznieks. Yeast anhydrobiosis and modern biotechnology: can they be connected? – In: 2nd Congress of Baltic Microbiologists. Book of Abstracts. Tartu, 2014, p. 57.

88.  L.Rozenfelde, A.Rapoport. Anhydrobiosis in yeast: AFM studies of yeast grown in conditions with severe oxygen limitation.- In: 2nd Congress of Baltic Microbiologists. Book of Abstracts. Tartu, 2014, p. 58.

89.  D.Borovikova, E.Dauss, S.Lisi, P.Buzzini, A.Rapoport. Gradual dehydration of Saccharomyces cerevisiae showed the critical points of changes in the activity of maltose transporter Agt1.- In: 2nd Congress of Baltic Microbiologists. Book of Abstracts. Tartu, 2014, p. 17.

90.  D.Borovikova, J.Freivalds, L.Rozenfelde, A.Rapoport. Benefits of immobilization for cells’ physiology.- In: 2nd Congress of Baltic Microbiologists. Book of Abstracts. Tartu, 2014, p. 18.

91.  M.Duskova, D.Borovikova, P.Herynkova, A.Rapoport, H.Sychrova. The role of glycerol transporters in yeast cells in various physiological and stress conditions.- FEMS Microbiol. Lett., 2015, vol. 362, 3, 1-8 (DOI: http://dx.doi.org/10.1093/femsle/fnu041)

92.  J.Liepins, E.Kovačova, K.Shvirksts, M.Grube, A.Rapoport, G.Kogan. Drying enhances immunoactivity of spent brewer’s yeast cell wall beta-D-glucans - J. Biotechnology, 2015, vol. 206, 12-16 (DOI: dx.doi.org/10.1016/j.jbiotec.2015.03.024)

93.  D.Borovikova, I.Muiznieks, A.Rapoport. New test-system based on the evaluation of yeast cells resistance to dehydration-rehydration stress. - The Open Biotechnology Journal, 2015, 9, 49-53 (DOI: 10.2174/1874070701509010049)

94.  L.Rozenfelde, M.Puke, I.Kruma, N.Matjuskova, N.Vedernikovs, A.Rapoports. Method of enzymatic hydrolysis of wheat straw lignocellulose.- Latvian Patent, 2015, LV15064 B

95.  A.Rapoport, D.Borovikova, L,Rozenfelde, S.Lisi, P.Buzzini. Anhydrobiosis in yeast: unique state of live organisms and its possible non-conventional applications. 32nd International Specialized Symposium on Yeasts “Yeast Biodiversity and Biotechnology in the Twenty-First Century. Book of Abstracts, Perugia. 2015, p. 16.

96.  D.Borovikova, R.Teparic, V.Mrsa, A.Rapoport. Anhydrobiosis in yeast: cell wall mannoproteins are important for yeast Saccharomyces cerevisiae resistance to dehydration.- Yeast, 2016, 33, 8, 347-353 DOI: 10.1002/yea.3164

97.  A.Rapoport, B.Turchetti, P.Buzzini. Application of anhydrobiosis and dehydration of yeasts for non-conventional biotechnological goals (Review).- World J. Microbiol. Biotechnol., 2016, 32(6):104 (DOI: 10.1007/s11274-016-2058-8)

98.  A.Rapoport,  D.Kulikova, O.Muter, H.Sychrova, P.Buzzini. Anhydrobiosis in yeasts: basic mechanisms and applications in biotechnology,- In: 14th International Congress on Yeasts. Abstracts. Awaji, Yumebutai, Hyogo, Japan, 2015, 147.

99.  R.Daugelavicius, N.Venslauskaite, L.Beiliunaite, D.Kulikova, A.Rapoport. Physiological changes in Saccharomyces cerevisie cells during dehydration/rehydration.- In: 14th International Congress on Yeasts. Abstracts. Awaji, Yumebutai, Hyogo, Japan, 2015, 148.

100. J.Brandenburg, I.Poppele, J.Blomqvist, A.Rapoport, V,Passoth. Lipid and ethanol production from straw hydrolysate after furfural extraction.- 14th International Congress on Yeasts. Abstracts. Awaji, Yumebutai, Hyogo, Japan, 2015, 239.

101. A.Rapoport, D.Kulikova, L.Rozenfelde. Anhydrobiosis in yeasts: from live nature to modern biotechnologies.- In: 3rd Congress of Baltic Microbiologists. Book of Abstracts. Vilnius, 2016, 28.

102. D.Kulikova, A.Liepina, G.Soveral, A.Rapoport. The role of aquaporins during Saccharomyces cerevisiae dehydration-rehydration.- In: 3rd Congress of Baltic Microbiologists. Book of Abstracts. Vilnius, 2016, 38.

103. L.Rozenfelde, M.Puke, I.Kruma, N.Vedernikov, N.Matjuskova, A.Rapoport. Enzymatic hydrolysis of ligno(hemi)cellulose after pretreatment with laccase.- In: 3rd Congress of Baltic Microbiologists. Book of Abstracts. Vilnius, 2016, 96.

104.  N.Venslauskaite, L.Beiliunaite, D.Kulikova, A.Rapoport, R.Daugelavicius. Potentiometric analysis of Saccharomyces cerevisiae cells during dehydration/rehydration.- In: 3rd Congress of Baltic Microbiologists. Book of Abstracts. Vilnius, 2016, 108.

105. Rapoport A., Rozenfelde L., Kulikova D., Khroustalyova G., Grube M., Buzzini P., Soveral G., Sibirny A. (2017) Anhydrobiosis in yeasts: mechanisms of cell resistance, In: 33rd International Specialized Symposium on Yeasts “Exploring and Engineering Yeasts for Industrial Application”. Abstracts. Cork, Ireland, 2017, 45.

106. A.Rapoport. Anhydrobiosis and dehydration of yeasts (Review).- In: Biotechnology 
of Yeasts and Filamentous Fungi (Ed. A.Sibirny). Springer International Publishing, 2017, 87-116 (DOI: 10.1007/978-3-319-58829-2_4).

107. N.Matjuskova, L.Okmane, D.Zala, L.Rozenfelde, M.Puke, I.Kruma, N.Vedernikovs, 
A.Rapoport. Effect of lignin-containing media on growth of medicinal mushroom Lentinula edodes. Proceedings of the Latvian Academy of Sciences. Section B, 2017, 71(1-2), 38-42 (DOI: 10.1515/prolas-2017-0007).

108. L.Rozenfelde, M.Puke , I.Kruma , I.Poppele, N.Matjuskova, N.Vedernikovs , 
A.Rapoport. Enzymatic hydrolysis of lignocellulose for bioethanol production.- Proceedings of the Latvian Academy of Sciences. Section B, 2017, 71(4), 275-279 (DOI: 10.1515/prolas-2017-0046).