Vislielākais burtu izmērs
Lielāks burtu izmērs
Burtu standarta izmērs
Department of Physical Chemistry
Last Update
12.10.2015

Adress: Jelgavas street 1, LV-1004, Riga
Phone
: +371 67033900, +371 29498924
E-mail: aactins@latnet.lv
Head:
asoc.prof.. Andris Actiņš

Research directions:   study of thermodynamically stable crystal forms in pharmaceutically active ingredients and kinetics of phase transition in compliance with development of technological production processes; materials based on smectite clay as raw material for the national economy; usage of undamaging methods in forensic expertise.



Academic staff:

Ass. Prof. Andris Actiņš; aactins@latnet.lv
Prof. Juris Pauls Kreišmanis, jpk@lu.lv
Ass. Prof. Pēteris Mekšs, trusens@latnet.lv
Doc. Sigurds Takeris, stakeris@latnet.lv
Doc. Guntars Vaivars, Guntars.Vaivars@cfi.lu.lv

Research:
The Head of Department is Ass. prof. A.Actiņš (since 1998). The main research in the department in carried out through 2 laboratories: X-ray analysis (Ass.prof. A.Actiņš) and chromatography (Ass.prof. P.Mekšs). Using modern instrumentation carry out research in diverse areas such as physical chemistry of solid active pharmaceutical ingredients, developing innovative chemical technologies by using chromatography methods, nanomaterial surface modification and studying local smectite clay minerals and membrane materials.
The department is publishing about 15 research papers and preparing 9-10 presentations at international conferences per year. Recently, 4 PhD dissertations are defended and current 4 PhD students are doing research.

Collaboration partners:
1. Pharmaceutical company „Grindeks” (J.Romanovskis)
2. RTU Faculty of Materials Science and Applied Chemistry (U.Sedmalis, J.Zicāns)
3. UL Faculty of Geography and Earth Sciences (Ģ.Stinkulis, V Segliņš, M.Kļaviņš)
4. Latvia Ministry of Justice, The State Forensic Science Bureau (G.Bebris)
5. UL Faculty of Medicine (R. Muceniece)
6. UL Faculty of Biology (I.Muižnieks)

Projects:
Research projects (current):
1.    Active pharmaceutical ingredient and air pollution studies by spektroscopic un X-ray methods (LSC funding). Project managers – A.Vīksna, A.Actiņš.
2.    Novel crystalline variations of active pharmaceutical ingredients and development of their industrial crystallization technologies (ERAF funding). Project manager A.Actiņš.
3.    Investigation of regularities of the influence of ionic liquids – environmentally friendly solvents on the transformation process of heterocyclic compounds. Project manager P.Mekšs and A.Zicmanis.

Significant research papers:
1.    A.Actins, R.Arajs, S.Belakovs, L.Orola, M.V.Veidis. The crystal and molecular structure of a polymorph and a pseudo-polymorph of droperidol. Journal of Chemical Crystallography, 2008, 38, 169.-174. lpp.
2.    I.Sarceviča, A.Actiņš. Smektītu mālu sorbcijas kapacitātes noteikšana. Latvijas Ķīmijas Žurnāls, 2009, Nr.3, 187.-196.lpp.
3.    A.Bērziņš, K.Krūkle, A.Actiņš, J. P.Kreišmanis. The relative stability of xylazine hydrochloride polymorphous forms. Pharmaceutical Development and Technology, 2010, vol.15, Nr.2, pp. 217-222.
4.    S.Petkune, A.Actiņš. Modeling phase transition kinetics of chenodeoxycholic acid with the Runge-Kutta method. Journal of Pharmaceutical and Biomedical Analysis., vol.53, Issue 1, sept. 2010, p. 7-14.
5.    L.Orola, M.V.Veidis. Nicotinamide fumaric acid supramolecular cocrystals:diversity of stoichiometry. CrystEngComn, 2009, 11, pp. 415-417.
6.    Zicmanis, S. Katkevica, P. Mekss. Lewis acid-catalyzed Beckmann rearragement of ketoximes in ionic liquids. Catalysis Communications, 2009, 10, pp.614-619.
7.    Nakurte, P.Mekss, K. Klavins, A. Zicmanis, G.Vavilina and S.Dubrovina. Collision-induced dissociation of imidazolium-based zwitterionic liquids. Eur.J.Mass Spectrom, 2009, 15, pp. 471-478.
8.    H. Luo, G. Vaivars, M. Mathe. Cross-linked PEEK-WC proton exchange membrane for fuel cell// International Journal of Hydrogen Energy 34 (2009) 8616-8621.
9.    H.Luo, G.Vaivars and M. Mathe. Covalent-ionically cross-linked polyetheretherketone proton exchange membrane for direct methanol fuel cell // Journal of Power Sources 195 (2010) 5197-5200.
10.    G.Vaivars. Datormodelēšanas izmantošana ķīmijas apguvei augstskolās (Computer modeling for chemistry teaching in universities). In: Starptautiskas zinātniski metodiskas konferences “’Ķīmijas izglītība 2010” rakstu krājums. Rīga. 2010. 94-98.lpp.